Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Extrusion – to form rod shaped particles of uniform diameter. Spheronization – to round off these rods into spherical particles. Drying – to.

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Extrusion / Spheronization

Capsugel offers a drug delivery technology extrusioj provide oral delivery with full enteric protection and rapid release in the upper gastrointestinal GI tract without the use of coatings.

The process consists of five operations. This dough then pressed through an extruder. Even if the ball-shaped extrudate is imperfect, the evenness of the surface still creates good conditions for subsequent coating.

In the pharmaceutical industry, pellets of medium particle sizes from to 2, micrometers are used for most applications. Just the way you need it. Join us for the multiparticulates webinar, where key considerations in designing multiparticulate formulations and processing will be discussed with representative case studies. Our Mini-tablets are a popular finished dosage form presentation and offers the benefits of multiparticulates while using established tableting technology. The process consists of four process extrusioj The exhrusion spheres are dried in a fluid bed dryer and particle size is selected by sieve cuts.

Agglomeration through extrusion and spheronization is one of the oldest techniques for manufacturing pellets. Please read our updated Cookies Policy for information about amd cookies we use and the information we collect. It is useful for making dense granules for controlled-release solid oral dosage forms with a minimum amount of excipients, as well as multiparticulates used for immediate, modified, or sustained-release.


Application of Multiparticulate Technologies for Drug Delivery. By continuing to use this website, you agree that we may store and access cookies on your device.

Primary packaging in either vials or sachets and secondary packaging services spheroniation also available.

Please note that Lonza has updated its Privacy Policy. By clicking “I Agree”, you confirm that you are above the age of 16, that you have read and understood the Privacy Policy and the Cookies Policy, and that you agree to the collection, use and processing of your Personal Information by Lonza in accordance with said policies. In other industries, the size of the pellets can spheronkzation several centimeters.

Extrusion & Spheronization Pharmaceutical Technology

Capsugel Dosage Form Solutions is offering a webinar that provides an overview of current taste masking approaches, with emphasis on two growing technology options. By Product Development Site. The wet extrudate is added to an LCI Marumerizer QJT spheronizer equipped with a high speed spinning plate which forms uniform spheres from the extrudate “rope”. Read more about it here! Capsugel has extensive experience and capabilities in optimizing pediatric and multiparticulate formulations.

Capsugel is well versed in using drug layering and modified-release coat layering to achieve a range of dissolution profiles in multiparticulate format.

The final drying ensures the pellet hardness. The technology chosen is dependent upon multiple active ingredient and formulation criteria, e. Register for An Account Already a member?

The diameter of the openings in the extrusion plate or extrusion basket determines the strength apheronization the elongated extrusion threads that result. The ratio of liquid to solid material together with the estrusion of the extruder holes significantly determines the quality of the extrudates.


For many pharmaceutical applications, extruded pellets are achieved in suitable quality if a sufficient portion of microcrystalline cellulose is added.

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The Extrusion Spheronization Processs

Capsugel has extensive experience in designing, formulating and scaling spheronisation dosage forms at feasibility, pilot and commercial scales. We also use cookies on our websites. Common applications include delayed release, extrusikn release, pulsatile release, and fixed dose combinations. Exxtrusion can disable cookies but parts of our website may not work. The dry, mixed, powdery active substances are kneaded into a dough with a liquid.

Cookies allow us to give you the best browsing experience and help us to understand how you use our site. For technical reasons, the resulting pellets are larger than micrometers. The wet spheronizarion is added into an LCI Multigranulator MG 55 where it is forced through a specific screen to form cylindrical extrudates using either dome, radial or axial extrusion for process optimization.

The coated spheres may be used for encapsulation, compression, or direct packaging into sachets or pouches for dosing. Moistening the powder mixture, forming cylinder-shaped agglomerate through extrusion, breaking and rounding the extrudate to round pellets through spheronization, and drying the finished product.

The spheres may undergo additional processing steps to apply functional or cosmetic coatings using fluid bed processing with a Wurster insert.